Identification of a neural development gene expression signature in colon cancer stem cells reveals a role for

Autor: Joseph L, Regan, Dirk, Schumacher, Stephanie, Staudte, Andreas, Steffen, Ralf, Lesche, Joern, Toedling, Thibaud, Jourdan, Johannes, Haybaeck, Nicole, Golob-Schwarzl, Dominik, Mumberg, David, Henderson, Balázs, Győrffy, Christian R A, Regenbrecht, Ulrich, Keilholz, Reinhold, Schäfer, Martin, Lange
Rok vydání: 2020
Zdroj: iScience. 25(7)
ISSN: 2589-0042
Popis: Recent evidence demonstrates that colon cancer stem cells (CSCs) can generate neurons that synapse with tumor innervating fibers required for tumorigenesis and disease progression. Greater understanding of the mechanisms that regulate CSC driven tumor neurogenesis may therefore lead to more effective treatments. RNA-sequencing analyses of ALDH
Databáze: OpenAIRE