[Research progress of targeting macrophage surface receptors in the treatment of inflammatory bowel disease]

Autor: Ludan, Zhang, Huimei, Xu, Tianyi, Wang, Bianli, Wang, Shangdi, Zhang, Dekui, Zhang
Rok vydání: 2022
Předmět:
Zdroj: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 38(5)
ISSN: 1007-8738
Popis: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a chronic inflammatory disorder of the gastrointestinal tract with unknown etiology and pathogenesis. In the intestinal tissues of IBD patients, dysregulation of macrophages results in persistent intestinal inflammation. Macrophages are highly adaptable and their phenotypes and functions could be regulated by various factors in the microenvironment via ligand-receptor binding, thus affecting the progression of the disease.
Databáze: OpenAIRE