| Autor: |
Zin, Naing, Benjamin, Rayner, Ananthen, Killikulangara, Krishna, Vunnam, Steven, Leach, Christopher J, McIver, Gillian M, Scott, Maria E, Craig, Kei, Lui, William D, Rawlinson |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Journal of paediatrics and child health. 49(3) |
| ISSN: |
1440-1754 |
| Popis: |
Premature neonates represent a population highly vulnerable to infection. This study aims to profile viral colonisation of gut and the associated clinical manifestations among premature neonates admitted to a neonatal intensive care unit (NICU) in Australia.In a cohort of 75 premature neonates born at less than 32 weeks gestation, who were followed for 4 weeks following admission to a NICU in Sydney, Australia, multiplex polymerase chain reaction assays were used to determine viral presence in stool, and clinical data were examined.Overall, viral RNA or DNA was detected in 24/419 (5.7%) of specimens, including norovirus genogroup 2 (1.9%), enterovirus (1.2%), herpes simplex virus-2 (1.2%), cytomegalovirus (0.7%), Epstein-Barr virus (0.5%) and rotavirus (0.2%). Viral infection was detected in 13/75 (17%) of premature neonates at some time point, including five (7%) neonates shedding more than one type of virus in stool. A higher rate of infection was observed among premature neonates with intrauterine growth restriction (56%) compared with those infants born appropriate for gestational age (12%. P = 0.006).The overall viral detection rate in stool of 5.7% (affecting 17% of neonates) indicates viral infections are an important health risk for premature infants in NICU. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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