| Autor: |
H, Wanner-Olsen, F B, Gaarskaer, E O, Mikkelsen, P, Jakobsen, B, Voldby |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
Chirality. 12(9) |
| ISSN: |
0899-0042 |
| Popis: |
After i.v. and oral administration of nimodipine the concentration-time profiles of the drug and its enantiomers were studied in seven patients with subarachnoid hemorrhage. Concentrations of nimodipine, (+)-(R)-, and (-)-(S)-nimodipine were analyzed using a new stereoselective high-performance liquid chromatographic method. During the first 3 h after oral administration the concentrations of (+)-(R)- and (-)-(S)-nimodipine were significantly different, the (-)-(S)-enantiomer being found in much lesser concentrations compared to the (+)-(R)-enantiomer. The results indicate that if uptake from the gastrointestinal system is equal for the two enantiomers, then (-)-(S)-nimodipine is metabolized at a much faster rate compared to (+)-(R)-nimodipine after oral administration of the drug in patients with subarachnoid bleeding. After i.v. administration; no significant differences between the concentrations of the (-)-(S) and the (+)-(R) isomers were demonstrated. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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