| Autor: |
J, Humljan, S, Starcević, V, Car, P, Stefanic Anderluh, D, Kocjan, B, Jenko, U, Urleb |
| Rok vydání: |
2008 |
| Předmět: |
|
| Zdroj: |
Die Pharmazie. 63(2) |
| ISSN: |
0031-7144 |
| Popis: |
UDP-N-acetylmuramic acid (UDP-MurNAc) is a substrate of MurC, an important enzyme in the intracellular pathway of bacterial peptidoglycan biosynthesis. Various approaches towards preparation of UDP-MurNAc have been published but these synthetic preparations were shown to include many problematic steps. An optimization study with the focus on muramyl phosphate and UMP-morpholidate coupling was performed, resulting in a synthetic procedure enabling robust and easily reproducible production on a multi-gram scale. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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