| Autor: |
A H, Buma, P, Beutels, P, van Damme, G, Tormans, E, van Doorslaer, A, Leentvaar-Kuijpers |
| Rok vydání: |
1998 |
| Předmět: |
|
| Zdroj: |
Military medicine. 163(8) |
| ISSN: |
0026-4075 |
| Popis: |
We analyzed the cost-effectiveness of hepatitis A vaccination regimens using a mathematical simulation model. Passive immunization and two active vaccination strategies (with and without prior screening) were compared with "doing nothing." Hepatitis A antibodies were determined in 2,325 Dutch marines; other input data were retrieved from published and unpublished sources. The prevalence of hepatitis A antibody was 14%. Screening before vaccination was identified as appropriate at a prevalence20%. Passive immunization was the cheapest prevention for a single 6-month deployment per 10 years. The inactivated vaccine containing 1,440 enzyme-linked immunosorbent assay units without prior screening was identified as the best option for more frequent deployments. It was cost-saving with two or more missions per 10 years. A 5.3% hepatitis A attack rate validated the investment for this policy. Overall, immunization with inactivated hepatitis A vaccine without prior screening proved to be the optimum strategy for troops at regular risk. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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