| Autor: |
C V, Sciortino, B R, Byers, P, Cox |
| Rok vydání: |
1980 |
| Předmět: |
|
| Zdroj: |
The Journal of laboratory and clinical medicine. 96(6) |
| ISSN: |
0022-2143 |
| Popis: |
Primary cultures of neonatal rat cardiac muscle cells incorporated radioiron from both [55Fe]transferrin and 59FeCl3 (added simultaneously). To evaluate the effect of iron chelators on such uptake, deferri chelators were added 6 hr after addition of the radioiron sources. The microbial chelator agrobactin was significantly more effective than the drug defoxamine in reduction of 55Fe uptake from [55Fe]transferrin; both chelators halted 59Fe3+ uptake. Agrobactin may have potential in chelation therpay for iron-overload disease. Certain other microbial chelators lowered radioiron uptake from either [55Fe]transferrin of 59FeCl3. These chelators should be useful inhibitors for studies of animal cell iron uptake and intracellular iron flow. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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