| Autor: |
Yu-Ting, Qin, Liu, Yao, Zhen, Yin, Shuang, Chen, Huan, Wang, Wen-Xia, Fan, Ming, Jiang, Jian-Ping, Hao |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Zhongguo shi yan xue ye xue za zhi. 28(5) |
| ISSN: |
1009-2137 |
| Popis: |
To study the expression of Shh singaling related gene, including Shh, Ptch1, Smo and Gli1 in bone marrow CD34The count of CD34The expression levels of Shh, Smo and Gli1 of patients in MDS and AML-MRC group were significantly higher than those in control group (P＜0.05), moreover increased with disease progression(P0.05). The expression of Ptch1 was not statistically significantly different between 3 groups（P＞0.05）. In comparison of prognosis, the expression of Smo and Gli1 in the patients of relatively high risk groups and AML-MRC groups were significantly increased (P0.05). The median overall survival time of patients in MDS and AML-MRC groups was 12（7.5，16.5） and 6（3.0，9.0） months (P=0.000) respectively. The median survival time of MDS and AML-MRC patients with high expression of Smo and Gli1 was significantly shorter than that of MDS and AML-MRC patients with low expression of Smo and Gli1(P0.05).Shh signaling pathway in the patients with MDS is activated, which is involved in the progress and prognosis of MDS.Shh信号通路在骨髓增生异常综合征和转白血病患者骨髓CD34研究Shh信号通路相关基因Shh、Ptch1、Smo和Gli1在骨髓增生异常综合征（MDS）和MDS转白血病(AML-MRC)患者骨髓CD34对53例MDS和30例AML-MRC患者采用流式细胞术检测骨髓CD34Shh、Smo和Gli1在MDS组和AML-MRC组患者中的表达水平均显著高于对照组 (P＜0.05)，且表达水平随疾病进展呈递增趋势（P＜0.05）；Ptch1表达在3组间差异无统计学意义（P＞0.05）。与相对低危组比较，Smo 和 Gli1 在相对高危组和AML-MRC组中的表达水平均明显增高(P＜0.05)。MDS组和AML-MRC组患者中位生存时间分别为12（7.5，16.5）和6（3.0，9.0）个月（P=0.000）。生存分析显示，MDS和AML-MRC 组中Smo 和 Gli1 高表达患者的中位生存时间明显短于低表达患者（P＜0.05）.MDS肿瘤干细胞中存在Shh信号通路的活化，其参与了MDS疾病进展并影响患者预后. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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