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Autor: Jasper A J, Smits, Marie-H, Monfils, Michael W, Otto, Michael J, Telch, Jason, Shumake, Justin S, Feinstein, Sahib S, Khalsa, Adam R, Cobb, E Marie, Parsons, Laura J, Long, Bryan, McSpadden, David, Johnson, Alma, Greenberg
Rok vydání: 2022
Předmět:
Zdroj: BMC psychiatry. 22(1)
ISSN: 1471-244X
0546-7683
Popis: Exposure-based therapy is an effective first-line treatment for anxiety-, obsessive-compulsive, and trauma- and stressor-related disorders; however, many patients do not improve, resulting in prolonged suffering and poorly used resources. Basic research on fear extinction may inform the development of a biomarker for the selection of exposure-based therapy. Growing evidence links orexin system activity to deficits in fear extinction and we have demonstrated that reactivity to an inhaled carbon dioxide (COWe will assess CORepresenting a necessary stage in translating basic research, this investigation addresses an important public health issue by testing an accessible clinical assessment strategy that may lead to a more effective treatment selection (personalized medicine) for patients with anxiety- and fear-related disorders, and enhanced understanding of the mechanisms governing exposure-based therapy.ClinicalTrials.gov Identifier: NCT05467683 (20/07/2022).
Databáze: OpenAIRE
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