| Autor: |
Pamella A, Malagrino, Carlos H G, Sponton, Rodrigo D, Esposti, Carla F, Franco-Penteado, Romulo A, Fernandes, Marcos André C, Bezerra, Dulcinéia M, Albuquerque, Cynara M, Rodovalho, Maurício, Bacci, Angelina, Zanesco |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Arquivos brasileiros de endocrinologia e metabologia. 57(1) |
| ISSN: |
1677-9487 |
| Popis: |
To evaluate the influence of the interaction between endothelial nitric oxide synthase gene (NOS3) polymorphisms at positions -786TC, Glu298Asp and intron 4b/a, and cardiorespiratory fitness on plasma nitrite/nitrate levels, blood pressure, lipid profile, and prevalence of cardiometabolic disorders.Ninety-two volunteers were genotyped for NOS3 polymorphisms at positions (-786TC and Glu298Asp) and (intron 4b/a) and divided according to the genotype: non-polymorphic (NP) and polymorphic (P). After that, they were subdivided according to the cardiorespiratory fitness associated with genotype: high (HNP and HP) and low (LNP and LP).The subjects with polymorphism for the interactions at positions Glu298Asp + intron 4b/a, and Glu298Asp+-786TC showed the highest values in total cholesterol, as well as dyslipidemia.Our findings show that NOS3 gene polymorphisms at positions -786TC, Glu298Asp, and intron 4b/a exert negative effects on the lipid profile compared with those who do not carry polymorphisms. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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