Long-term exposures to higher environmental temperature and body temperature: effect of chlorpromazine in relation to hypothalamic GABA

Autor:	D, Mukherjee, M K, Poddar
Rok vydání:	2001
Předmět:	Male Hot Temperature Chlorpromazine Hypothalamus Environmental Exposure Cholinergic Agonists Cholinergic Antagonists Body Temperature Rats GABA Antagonists Animals Dopamine Antagonists GABA Agonists gamma-Aminobutyric Acid
Zdroj:	Pharmacology, biochemistry, and behavior. 69(3-4)
ISSN:	0091-3057
Popis:	Treatment with a single dose of chlorpromazine (CPZ; 1 mg/kg, ip) at room temperature (28 degrees +/-0.5 degrees C) significantly reduced body temperature by its anticholinergic action. Long-term exposures to higher environmental temperature (40 degrees +/-0.5 degrees C, 2 h/day, for 30 consecutive days) increased body temperature significantly by reduction of hypothalamic GABAergic activity, but this increase in body temperature was attenuated from that observed with a single exposure to higher environmental temperature (40 degrees C for 2 h). Treatment with a single dose of CPZ on the last day of 30 consecutive days of exposures to higher environmental temperature increased body temperature of rats more than that observed with long-term exposures to higher environmental temperature possibly due to (i) reduction of hypothalamic GABAergic activity, (ii) heat dissipation and (iii) reverse-anticholinergic action of CPZ at higher environmental temperature.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c67f88b41ae9ecb7e059f14f181d94d4 https://pubmed.ncbi.nlm.nih.gov/11509197 Zobrazit plný text záznamu Full Text from ScienceDirect