| Autor: |
C, Lecot, V, Jeantils, L, Ovaguimian, A, Krivitzky, C, Bréchot, P, Dény |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Progress in clinical and biological research. 382 |
| ISSN: |
0361-7742 |
| Popis: |
We used the polymerase chain reaction (PCR) to detect hepatitis D (HD) viremia in patients infected with the human immunodeficiency virus (HIV). Nineteen (9%) of 206 such patients were prospectively found to be infected by HDV. Thirty-one anti-HIV-positive patients were studied by means of PCR and the results were analysed according to HDV and hepatitis B virus (HBV) serological status. HDV-PCR was positive in five patients. Two had detectable serum HDV antigen. Four patients had anti-HD IgM and IgG antibodies. All these patients were HBs antigen-positive, and three were HBV-DNA positive. All the other patients were HDV-PCR-negative. Statistical analysis suggested more extensive liver damage and immunological impairement in HDV-PCR positive patients. In this unselected HIV-infected population, HDV-RNA detection by PCR was only evidenced in HDV infected patients in whom 5/19 were positive. This test allowed direct diagnosis of HDV viremia and will be useful for the monitoring of HDV infection. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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