Splenic ischemic preconditioning attenuates oxidative stress induced by hepatic ischemia-reperfusion in rats 1

Autor:	Costa, Caio César Chaves, Pereira, Nathalia Gabay, Machado, Anna Luiza Melo, Dórea, Mariana Albuquerque, da Cruz, Rafaella Macêdo Monteiro, Silva, Renata Cunha, Domingues, Robson José de Souza, Yasojima, Edson Yuzur
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Male Liver Diseases Rats Oxidative Stress Disease Models Animal Random Allocation Experimental Surgery Liver Reperfusion Injury Animals Original Article cardiovascular diseases Rats Wistar Ischemic Preconditioning Liver Failure
Zdroj:	Acta Cirúrgica Brasileira
ISSN:	1678-2674 0102-8650
Popis:	Purpose: To evaluate the effects of splenic ischemic preconditioning (sIPC) on oxidative stress induced by hepatic ischemia-reperfusion in rats. Methods: Fifteen male Wistar rats were equally divided into 3 groups: SHAM, IRI and sIPC. Animals from IRI group were subjected to 45 minutes of partial liver ischemia (70%). In the sIPC group, splenic artery was clamped in 2 cycles of 5 min of ischemia and 5 min of reperfusion (20 min total) prior to hepatic ischemia. SHAM group underwent the same surgical procedures as in the remaining groups, but no liver ischemia or sIPC were induced. After 1h, hepatic and splenic tissue samples were harvested for TBARS, CAT, GPx and GSH-Rd measurement. Results: sIPC treatment significantly decreased both hepatic and splenic levels of TBARS when compared to IRI group (p
Databáze:	OpenAIRE
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