| Autor: |
Martin W von, Websky, Paul C, Wesselmann, Carolynne, Schwarze-Zander, Tim Oliver, Vilz, Burkhard, Stoffels, Christoph, Boesecke, Jürgen, Rockstroh, Jörg C, Kalff, Dimitrios, Pantelis |
| Jazyk: |
němčina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Zentralblatt fur Chirurgie. 144(4) |
| ISSN: |
1438-9592 |
| Popis: |
In HIVIn this study, we contrasted surgical resection and topical imiquimod therapy of HPV-associated anal lesions in HIVThis was a retrospective analysis of 97 HIVIn 53/97 patients (54%), HPV-associated anal disease was diagnosed upon the first visit. In approx. 50% of the patients, the HIV infection was adequately controlled (52 patients with viral load 40 copies [53.6%]) under cART. The mean age was 41.0 ± 11.6 years. In 7/53 patients with macroscopic C. ac., low-grade and in 18/53 patients high-grade AIN were additionally confirmed. Success rates of surgical resection, imiquimod treatment and the combination of the two were compared. Complete remission of C. ac. and AIN four weeks after treatment was considered a therapeutic success. For C. ac., success rates with imiquimod were 5/25 (20.0%) vs. surgery* 30/57 (52.6%, Mann-Whitney U test p 0.05) vs. surgery+imiquimod 7/15 (46.7%). For AIN, success rates with imiquimod were 4/24 (16.7%) vs. surgery* 47/83 (56.7%, Mann-Whitney U test p 0.05) vs. surgery+imiquimod 9/21 (42.8%). In 7/92 (13%) of surgical treatments, complications were reported: four minor and two significant bleeding episodes and one perianal thrombosis. No side effects of imiquimod were documented besides skin irritation.Surgery is more effective than topical imiquimod as initial therapy of HPV-related anogenital disease in HIVRegelmäßige proktologische Untersuchungen sind bei HIVEs sollte untersucht werden, ob sich chirurgische Abtragung und topische Therapie mit Imiquimod bez. Heilungsraten und Outcome bei HPV-assoziierten analen Läsionen unterscheiden und ob ein synergistischer Effekt vorliegt.Es wurden bei 97 HIVBei 53/97 (54%) HIVEine operative Erstbehandlung von HPV-assoziierten analen Läsionen bei HIV |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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