| Autor: |
Ernesto, Bosch, Anders, Nyboe Andersen, Pedro, Barri, Juan Antonio, García-Velasco, Petra, de Sutter, Manuel, Fernández-Sánchez, Hana, Visnova, Bjarke M, Klein, Bernadette, Mannaerts, Joan-Carles, Arce |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Clinical endocrinology. 83(6) |
| ISSN: |
1365-2265 |
| Popis: |
To study the association between serum anti-Müllerian hormone (AMH) levels and follicular development and endocrine responses induced by increasing doses (5·2-12·1 μg/day) of a novel recombinant human FSH (rhFSH, FE 999049) in patients undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) in a GnRH antagonist protocol.Secondary analysis of a randomized controlled trial with stratified randomization according to AMH (lower stratum: 5·0-14·9 pmol/l; higher stratum: 15·0-44·9 pmol/l).Infertile women of good prognosis (n = 265).Follicular development and endocrine parameters during controlled ovarian stimulation (COS) with rhFSH.Serum FSH levels increased with increasing rhFSH doses and steady-state levels for each dose were similar in both AMH strata. In the whole study population, significant (P0·001) positive dose responses were observed for the number of follicles ≥ 12 mm, and serum levels of oestradiol, inhibin B, inhibin A and progesterone at end of stimulation. In comparison with the higher AMH stratum, patients in the lower AMH stratum had significantly different slopes of the dose-response curves for these hormones, and no clear dose-related increase was observed for the number of follicles in these patients.Dose-response relationships between rhFSH and follicular development and endocrine parameters are significantly different for IVF/ICSI patients with lower and higher serum AMH levels at start of COS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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