| Autor: |
Carlos A, Tirado, Karen, Cunnien, Katie, Lapp, Diane, Serk, Jennifer, Rankin, John, Ewing, Jacqueline, Han, David, Chung, Andrew, Reyes, Kevin, Stielgbauer |
| Rok vydání: |
2019 |
| Zdroj: |
Journal of the Association of Genetic Technologists. 45(4) |
| ISSN: |
1523-7834 |
| Popis: |
Diffuse large B-cell lymphoma (DLBCL) is a non-Hodgkin's lymphoma (NHL) that is the most common and the most aggressive or fast-growing form of NHL. It can lead to death if left untreated. Cytogenetic abnormalities include rearrangements of the IgH and BCL2 genes. Herein we described a t(8;14;22)(q24;q32;q11.2) within the context of a complex karyotype involving MYC/IGH/IGL in a three-way translocation that was characterized by molecular cytogenetics. The t(8;14)(q24;q32) is a recurrent chromosome abnormality described in non-Hodgkin lymphomas (NHL), especially in 80% of Burkitt lymphoma (BL) and diffuse large B-cell lymphomas. The variant t(8;22) (q24;q11) is also seen in these cases. MYC rearrangements have been observed in up to 10% of cases of diffuse large B-cell lymphomas (DLBCL) and is usually associated with a complex pattern of genetic alterations. This particular pattern with IGH-MYC rearrangements within the context of complex karyotypes is seen in diffuse large B-cell lymphomas. Complex karyotypes are associated with genomic instability and a poor prognosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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