| Autor: |
W, Ahlswede, S, Michels, R, Birngruber, U, Schmidt-Erfurth |
| Jazyk: |
němčina |
| Rok vydání: |
2004 |
| Předmět: |
|
| Zdroj: |
Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft. 101(7) |
| ISSN: |
0941-293X |
| Popis: |
Photodynamic therapy (PDT) induces occlusive and regenerative effects in choroidal neovascularization (CNV) and physiological choroid. The process of vascular alteration is documented quantitatively and qualitatively by three-dimensional angiography.In a prospective, randomized trial 30 patients with subfoveal CNV due to age-related macular degeneration (AMD) were treated with PDT or placebo. Fluorescence series with 32 tomographic images over a 4-mm depth were analyzed topographically and reproduced in a three-dimensional display.At initial presentation CNV lesions were documented as a well-defined prominence in all patients. In the verteporfin group CNV height continuously decreased with each interval. In the placebo group CNV slightly increased in height during the first 6 months and remained stable at about 90% of the initial prominence at long-term follow-up. After 12 months 44% of the patients in the verteporfin group developed an additional choroidal defect.Three-dimensional angiography offers a reliable documentation of CNV progression and regression during PDT. A decrease in CNV size is associated with an increase in choroidal perfusion defects. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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