Molecular biology of nickel carcinogenesis

Autor:	M, Costa, J E, Sutherland, W, Peng, K, Salnikow, L, Broday, T, Kluz
Rok vydání:	2001
Předmět:	X Chromosome Phagocytosis Nickel Heterochromatin Yeasts Carcinogens Animals Humans Gene Silencing DNA Methylation Telomere
Zdroj:	Molecular and cellular biochemistry. 222(1-2)
ISSN:	0300-8177
Popis:	A review of the molecular mechanisms of nickel carcinogenesis has been compiled. This work is based upon approximately 20 years of research conducted in my laboratory. Molecular mechanisms of nickel carcinogenesis are considered from the point-of-view of the uptake of nickel, both soluble and insoluble particles in cells, its dissolution and its effects on heterochromatin. Molecular mechanisms by which nickel induces gene silencing in cells by DNA hypermethylation in mammalian cells and by inhibiting histone acetylation in yeast cells are also discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c59467badfed390b2fa3995a1029bdbb https://pubmed.ncbi.nlm.nih.gov/11678603 Zobrazit plný text záznamu Full text from SpringerLink