Heilaohuacid G, a new triterpenoid from Kadsura coccinea inhibits proliferation, induces apoptosis, and ameliorates inflammation in RA-FLS and RAW 264.7 cells via suppressing NF-𝜅B pathway

Autor:	Yu-Pei, Yang, Yu-Qing, Jian, Yong-Bei, Liu, Qing-Ling, Xie, Huang-He, Yu, Bin, Wang, Bin, Li, Cai-Yun, Peng, Wei, Wang
Rok vydání:	2022
Předmět:	Inflammation Lipopolysaccharides Ethanol Plant Extracts Synovial Membrane NF-kappa B Apoptosis Fibroblasts Xylenes Sincalide Triterpenes Arthritis Rheumatoid Mice RAW 264.7 Cells Kadsura Osteoarthritis Animals Cytokines Rheumatic Fever Cells Cultured Cell Proliferation
Zdroj:	Phytotherapy research : PTRREFERENCES. 36(10)
ISSN:	1099-1573
Popis:	Heilaohu, the roots of Kadsura coccinea, has been used in Tujia ethnomedicine to treat rheumatic arthritis (RA). Heilaohuacid G (1), a new 3,4-seco-lanostane type triterpenoid isolated from the ethanol extract of Heilaohu, whose structure was determined using HR-ESI-MS data, NMR spectroscopic analyses, and ECD calculations. In this study, our purpose is to elucidate the mechanisms of Heilaohuacid G in the treatment of RA by inhibited proliferation of rheumatoid arthritis-fibroblastoid synovial (RA-FLS) cells and inhibited the inflammatory reactions in LPS-induced RA-FLS and RAW 264.7 cell lines via inhibiting NF-κB pathway. The biological activity screening experiments indicated that Heilaohuacid G significantly inhibited proliferation of RA-FLS cells with IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c52489e125f6816058d8c439c22c756a https://pubmed.ncbi.nlm.nih.gov/36104304 Zobrazit plný text záznamu Plný text