| Autor: |
V, Daraki, T, Roumeliotaki, G, Chalkiadaki, M, Katrinaki, M, Karachaliou, V, Leventakou, M, Vafeiadi, K, Sarri, M, Vassilaki, S, Papavasiliou, M, Kogevinas, L, Chatzi |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Pediatric obesity. 13(8) |
| ISSN: |
2047-6310 |
| Popis: |
Vitamin D may modulate adipogenesis. However, limited studies have investigated the effect of maternal vitamin D during pregnancy on offspring adiposity or cardiometabolic parameters with inconclusive results.The objective of this study is to examine the association of maternal 25(OH)-vitamin D [25(OH)D] status with offspring obesity and cardiometabolic characteristics in 532 mother-child pairs from the prospective pregnancy cohort Rhea in Crete, Greece.Maternal 25(OH)D concentrations were measured at the first prenatal visit (mean: 14 weeks, SD: 4). Child outcomes included body mass index standard deviation score, waist circumference, skin-fold thickness, blood pressure and serum lipids at ages 4 and 6 years. Body fat percentage was also measured at 6 years. Body mass index growth trajectories from birth to 6 years were estimated by mixed effects models with fractional polynomials of age. Adjusted associations were obtained via multivariable linear regression analyses.About two-thirds of participating mothers had 25(OH)D concentrations50 nmol LExposure to very low 25(OH)D concentrations in utero may increase childhood adiposity indices. Given that vitamin D is a modifiable risk factor, our findings may have important public health implications. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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