FGFs, heparan sulfate and FGFRs: complex interactions essential for development

Autor:	D M, Ornitz
Rok vydání:	2000
Předmět:	Fibroblast Growth Factors Heparin Animals Drosophila Tissue Distribution Heparitin Sulfate Models Biological Receptors Fibroblast Growth Factor Signal Transduction
Zdroj:	BioEssays : news and reviews in molecular, cellular and developmental biology. 22(2)
ISSN:	0265-9247
Popis:	Fibroblast growth factors (FGFs) comprise a large family of developmental and physiological signaling molecules. All FGFs have a high affinity for the glycosaminoglycan heparin and for cell surface heparan sulfate proteoglycans. A large body of biochemical and cellular evidence points to a direct role for heparin/heparan sulfate in the formation of an active FGF/FGF receptor signaling complex. However, until recently there has been no direct demonstration that heparan is required for the biological activity of FGF in a developmental system in vivo. A recent paper by Lin et al.(1) has broken through this barrier to demonstrate that heparan sulfate is essential for FGF function during Drosophila development. The establishment of a role for heparan sulfate in FGFR activation in vivo suggests that tissue-specific differences in the structure of heparan may modulate the activity of FGF. BioEssays 22:108-112, 2000.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c4bfde3356acec5e39bd55d113b9d10d https://pubmed.ncbi.nlm.nih.gov/10655030 Zobrazit plný text záznamu Plný text