Yeppoonic acids A - D: 1,2,4-trisubstituted arene carboxylic acid co-metabolites of conglobatin from an Australian Streptomyces sp

Autor:	Heather, Lacey, Rachel, Chen, Daniel, Vuong, Michael S, Cowled, Ernest, Lacey, Peter J, Rutledge, Andrew M, Piggott
Rok vydání:	2021
Předmět:	Male Antibiotics Antineoplastic Australia Carboxylic Acids Prostatic Neoplasms Streptomyces Anti-Bacterial Agents Mice Cell Line Tumor Animals Humans Queensland Multiple Myeloma Oxazoles Soil Microbiology
Zdroj:	The Journal of antibiotics. 75(2)
ISSN:	1881-1469
Popis:	Streptomyces sp. MST-91080 was isolated from a soil sample collected in Queensland, Australia. From this strain, yeppoonic acids A - D were purified and spectroscopically characterised. The yeppoonic acids are a family of diene enecarboxylic acids on a 1,2,4-trisubstituted benzene scaffold, structurally related to other Streptomyces secondary metabolites MF-EA-705α/β, NFAT-133 and the lorneic acids. Yeppoonic acids B and C show strong cytotoxicity against the NS-1 mouse myeloma cell line (IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c4b7a5d4486a3c2559d3f9f137bdeb36 https://pubmed.ncbi.nlm.nih.gov/34880415 Zobrazit plný text záznamu Full text from SpringerLink