| Autor: |
M D, Hogan, L L, Kupper, B M, Most, J K, Haseman |
| Rok vydání: |
1978 |
| Předmět: |
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| Zdroj: |
American journal of epidemiology. 108(1) |
| ISSN: |
0002-9262 |
| Popis: |
K.J. Rothman has explored in some detail the issue of assessing the potential presence of synergism (or antagonism) in data generated from either a cohort or a case-control study. Arguing that the "natural" scale for quantifying the joint effects of two or more factors acting in combination is the probability scale, he has proposed a procedure based on a ratio-type index for evaluating two-factor interaction in the presence of non-zero background effects. In this paper, the authors review the rationale underlying Rothman's approach for a cohort study. They then present what they maintain is a simpler and more appropriate test procedure (utilizing a linear contrast of the observed risks) for the additive approximation to his basic probabilistic model of "no interaction." A likelihood ratio test based on his original model is also proposed, as well as a closed form approximation to it. Finally, the assessment of interaction in cohort studies involving exposure factors measured at more than two levels is addressed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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