| Autor: |
D, Adler, D, Kürktschiev, S, Subat, H U, Lehmann, K U, Schentke |
| Jazyk: |
němčina |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Zeitschrift fur Gastroenterologie. 31(2) |
| ISSN: |
0044-2771 |
| Popis: |
Investigations concerning changes of dipeptidyl-peptidase IV-positive (DP IV+) lymphocytes in the peripheral blood (PBL) were undertaken in 22 patients with primary biliary cirrhosis (PBC) under therapy with ursodeoxycholic acid (750 mg/day). We found that after 4-8 weeks of therapy the number of DP IV+ PBL was raised from an initially low, suppressed level of 5-12% to 18-33% corresponding to the range observed in healthy subjects. Concurrently liver function parameters of the patients were significantly improved. The identity of DP IV+ CD 26+ peripheral T-cells could be shown by the combination of cytochemical DP IV-staining with the indirect immuno-fluorescence of the lymphocyte marker CD 26. These results show that the UDCA-therapy in patients with PBC has a direct effect on the immune system and a positive influence on the immuno-regulative capacity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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