| Autor: |
Angela Beatrice, Scardovi, Renata, De Maria, Claudio, Colettat, Nadia, Aspromonte, Silvia, Perna, Tommaso, Infusino, Paola, D'Errigo, Stefano, Rosato, Manuela, Greggi, Tiziana, Di Giacomo, Roberto, Riccio, Vincenzo, Cec |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
Medical science monitor : international medical journal of experimental and clinical research. 12(5) |
| ISSN: |
1234-1010 |
| Popis: |
Whether brain natriuretic peptide (BNP), a neurohormone marker of ventricular dysfunction, correlates with an enhanced ventilatory response (EVR) during cardiopulmonary exercise test, a well-known predictor of prognosis, in systolic heart failure (HF) is currently unknown.Resting BNP was measured in 134 consecutive stable outpatients aged 69 +/- 11 years with mild to moderate HF and LV ejection fraction (LVEF)40% who performed a maximal exercise test. EVR was assessed as the slope of the relation between minute ventilation and carbon dioxide production (VE/VCO2 slope)or = 35.LVEF averaged 33 +/- 7%, BNP 350 +/- 396 pg/ml, and the VE/VCO2 slope 36 +/- 8. Fifty-six of 123 patients (45%) had EVR. BNP correlated with VE/VCO2 slope (r = 0.453; p0.01). By multivariate logistic regression, plasma BNP was the only independent predictor of EVR (RR: 1.004 per unit increment, 95% CI: 1.002-1.006, p0.0001). A BNPor = 160 pg/ml had 86% sensitivity, 67% specificity, and 76% overall accuracy for the prediction of EVR (chi square: 37.4, RR 12.2, 95% CI: 4.96-30.3, p0.0001, AUC 0.815 (95%CI. 0.738-0.892)).In systolic HF, plasma BNP is related to an enhanced ventilatory response to exercise and offers a simple and reliable alternative to the cardiopulmonary exercise test in patients with inability or contraindications to exercise. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
