| Autor: |
I V, Romanova, A Iu, Chesnokova, A L, Mikhrina |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 98(8) |
| ISSN: |
0869-8139 |
| Popis: |
The increase of CART-peptide optical density was found immunohistochemically in nucleus accumbens neurons and in their terminals in substantia nigra in Wistar rats after 28% reduction of dopaminergic neurons in a substantia nigra (in the model of lactacystin induced proteo some disfunction). At the same time after in vitro incubation of nigro-accumbal brain slice with AMPT (alpha-methyl-paratirosine--dopamine inhibitor) for 4 h the reduction of tyrosine hydroxylase optical density (the enzyme limiting dopamine synthesis) in substantia nigr neurons was found and optical density of CART-peptide in nucleus accumbens and substantia nigra was also revealed. In both experiments data about activation of CARTergic neurons in stria to-nigral projections testifies on participation of CART-peptide in compensatory brain mechanisms at dopamine loss and its role as modulator of dopaminergic brain neurons functional activity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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