| Autor: |
J, Hu-Li, C, Pannetier, L, Guo, M, Löhning, H, Gu, C, Watson, M, Assenmacher, A, Radbruch, W E, Paul |
| Rok vydání: |
2001 |
| Předmět: |
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| Zdroj: |
Immunity. 14(1) |
| ISSN: |
1074-7613 |
| Popis: |
CD4 cells from mice heterozygous for an IL-4 and a GFP/IL-4 gene frequently express a single allele. Analysis of IL-4 or GFP production by cells from recently primed Th2 cells indicates that essentially all are competent to transcribe either allele but have a low probability of doing so. By contrast, long-term Th2 clones show distinct and heritable ratios in the proportion of cells that express IL-4 or GFP. We conclude that in the course of Th2 priming an early efficient event renders both alleles capable of being inefficiently transcribed; a second, less frequent event occurs that renders one allele more competent, accounting for the differential expression of IL-4 and GFP in different clones. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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