| Autor: |
Ana, Moreno, Jesús, Fortún, Javier, Graus, Miguel A, Rodriguez-Gandía, Carmen, Quereda, María J, Pérez-Elías, Javier, Nuño, Philip, Wikman, Santiago, Moreno, Rafael, Bárcena |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 17(3) |
| ISSN: |
1527-6473 |
| Popis: |
Statins are relatively safe first-line agents to use in the setting of dyslipidemia associated with immunosuppressive therapy in subjects undergoing liver transplantation, and also in HIV-infected patients with dyslipidemia due to antiretroviral drugs, especially ritonavir-boosted protease inhibitors. Rosuvastatin, a new statin, has demonstrated higher potency than previously released statins and is not extensively metabolized by the liver P450 system; therefore, the probability of deleterious pharmacokinetic interactions with commonly used immunosuppressants and antiretroviral drugs is reduced. We present the first case of severe rhabdomyolysis in a liver transplant patient receiving rosuvastatin for the treatment of immunosuppressive therapy-related grade IV dyslipidemia, an HIV-infected subject on protease inhibitor-sparing HAART, that resolved after rosuvastatin withdrawal, probably related to interactions between calcineurin inhibitors and hepatic rosuvastatin uptake transporters such as organic anion transporting polypeptides (OATPs). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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