| Autor: |
Sathe, Meghana, Huang, Rong, Heltshe, Sonya, Eng, Alexander, Borenstein, Elhanan, Miller, Samuel I., Hoffman, Lucas, Gelfond, Daniel, Leung, Daniel H., Borowitz, Drucy, Ramsey, Bonnie, Freeman, A. Jay |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
J Pediatr Gastroenterol Nutr |
| Popis: |
OBJECTIVES: To identify factors that increase risk of gastrointestinal-related (GI-related) hospitalization of infants with cystic fibrosis (CF) during the first year of life. METHODS: The Baby Observational and Nutrition Study was a longitudinal, observational cohort of 231 infants diagnosed with CF by newborn screening. We performed a post-hoc assessment of the frequency and indications for GI-related admissions during the first year of life. RESULTS: Sixty-five participants had at least one admission in the first 12 months of life. High pancreatic enzyme replacement therapy (PERT) dosing (>2000 LU/kg/meal) (hazard ratio, HR=14.75, p=0.0005) and use of acid suppressive medications (HR=4.94, p=0.01) during the study period were positively associated with subsequent GI-related admissions. High levels of fecal calprotectin (fCP) (>200 μg/g) and higher relative abundance of fecal Klebsiella pneumoniae were also positively associated with subsequent GI-related admissions (HR=2.64, p=0.033 and HR=4.49, p=0.002, respectively). During the first 12 months of life, participants with any admission had lower weight-for-length z-scores (WLZ) (p=0.01). The impact of admission on WLZ was particularly evident in participants with a GI-related admission (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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