| Autor: |
S, Del Sol-Fernández, Y, Portilla-Tundidor, L, Gutiérrez, O F, Odio, E, Reguera, D F, Barber, M P, Morales |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
ACS applied materialsinterfaces. 11(30) |
| ISSN: |
1944-8252 |
| Popis: |
Despite the potential of magnetic nanoparticles (NPs) to mediate intracellular hyperthermia when exposed to an alternating magnetic field (AMF), several studies indicate that the intracellular heating capacity of magnetic NPs depends on factors such as cytoplasm viscosity, nanoparticle aggregation within subcellular compartments, and dipolar interactions. In this work, we report the design and synthesis of monodispersed flowerlike superparamagnetic manganese iron oxide NPs with maximized SAR (specific absorption rate) and evaluate their efficacy as intracellular heaters in the human tumor-derived glioblastoma cell line U87MG. Three main strategies to tune the particle anisotropy of the core and the surface to reach the maximum heating efficiency were adopted: (1) varying the crystalline anisotropy by inserting a low amount of Mn |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
