| Autor: |
Rachel M, Kaplan, Charles A, Herzog, Brett, Larive, Haris, Subacius, Bruce D, Nearing, Richard, Verrier, Rod S, Passman |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc. 21(6) |
| ISSN: |
1542-474X |
| Popis: |
BACKGROUND: Hemodialysis (HD) patients are at high risk of sudden cardiac death (SCD). HD 6‐times/week (6x/wk) may reduce SCD risk compared to usual 3‐times/week HD (3x/wk) by mechanisms unknown. T‐wave alternans (TWA), heart rate turbulence (HRT), and ventricular ectopy (VE) are elevated in HD patients, but their response to 6x/wk HD has not been assessed. METHODS: Baseline and 1‐year Holter recordings were analyzed from enrollees in the Frequent Hemodialysis Network Daily Trial, a randomized trial comparing 3x/wk to 6x/wk in 245 chronic HD patients. TWA, HRT, and VE were assessed using MARS software. RESULTS: Sixty‐eight patients (34 with 6x/wk) had complete baseline and 1‐year Holter recordings. Mean age was 50 ± 13 years and 38% were female. Maximum TWA in the 3x/wk and 6x/wk groups were 52.4 μV at baseline and 51.2 μV at 1‐year versus 54.0 and 49.9 μV, respectively (P = 0.28). The proportion of abnormal HRT (scores of 1 or 2) in the 3x/wk group decreased from 65% to 56% at 1‐year versus 53% to 53% in the 6x/wk group (P = 0.58). Mean %VE changed from 1.6% to 2.9% in the 3x/wk group from baseline to 1‐year and from 2.1% to 3.7% in the 6x/wk group (P = 0.85). CONCLUSIONS: There were no significant differences in HRT or VE at 1‐year in chronic HD patients randomized to 6x/wk versus 3x/wk and a trend in TWA reduction. Additional studies are needed to evaluate the impact and mechanisms of SCD in HD. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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