| Autor: |
N A, Golubkina, V K, Mazo, I V, Gmoshinskiĭ, S N, Zorin, A Kh, Tambiev, N N, Kirikova |
| Rok vydání: |
2000 |
| Předmět: |
|
| Zdroj: |
Voprosy meditsinskoi khimii. 46(1) |
| ISSN: |
0042-8809 |
| Popis: |
The main events caused by anaphilaxis in selenium haemostasis in rats include significant increase of selenium excretion with urine (6.36 +/- 1.18 nM Se/18 h., n = 10, compared with 1.72 +/- 0.38 nM Se/18 h., n = 10) and decrease of selenium plasma/selenium erythrocytes ratio from 0.939 to 0.791. Reduced glutathione (G-SH) administration led to 1.5-fold decrease of plasma selenium level and 1.3-fold increase of selenium concentration in intestinal walls of sensitized rats (r = -0.720, P0.001). Chromatographic separation of plasma proteins showed that intragastric intubation of G-SH to sensibilized rats significantly decreased the protein P content and did not influence the concentration of Se-GSHPx, thus indicating the local selenium acceptor role of G-SH. G-SH administration did not influence the intestinal permeability in sensitised rats while use of complex additive: G-SH and selenium enriched spirulina--normalized the latter parameter and the ratio of protein P/Se-GSHPx in plasma. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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