| Autor: |
R, Bedry, L, Deschamps, F, Pehourcq, N, Moore, O, Pillet, J C, Favarel-Garrigues |
| Rok vydání: |
1999 |
| Předmět: |
|
| Zdroj: |
Veterinary and human toxicology. 41(1) |
| ISSN: |
0145-6296 |
| Popis: |
A 29-y-old male attempted suicide with 3000 mg clozapine, 150 mg zopiclone, alprazolam and unknown quantities of alcohol. He was admitted in a deep hypotonic coma with respiratory depression, inhalation pneumonia and vascular collapse. Symptomatic treatment involved mechanical ventilation, vascular filling and antibiotics. The patient was discharged from the Intensive Care Unit 72 h after the suicide attempt with no sequelae. To detect and quantify clozapine in plasma, high-pressure liquid chromatography showed a 4 h absorption phase and a peak serum concentration of 5200 ng/ml. Three successive elimination t1/2 values of 38, 24 and 13 h were calculated. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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