Expression of Laminin in Oral Squamous Cell Carcinomas

Autor:	Yellapurkar, Shweta, Natarajan, Srikant, Boaz, Karen, Manaktala, Nidhi, Baliga, Mohan, Shetty, Premalatha, Prasad, Mukul, Ravi, Mahalakshmi
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Male Cytoplasm Middle Aged Prognosis basement membrane Lymphatic Metastasis Biomarkers Tumor Carcinoma Squamous Cell Humans Female Mouth Neoplasms Neoplasm Invasiveness Laminin OSCC Neoplasm Recurrence Local Research Article Follow-Up Studies
Zdroj:	Asian Pacific Journal of Cancer Prevention : APJCP
ISSN:	2476-762X 1513-7368
Popis:	Background and objectives: Laminin is a significant basement membrane (BM) glycoprotein, the expression of which reflects BM integrity more precisely than do other ECM proteins. The present study aimed to evaluate laminin expression in oral squamous cell carcinomas OSCC and to determine any associations with clinico-pathological parameters (surgical margin status, lymph node involvement, survival and recurrence). Methods: Laminin expression was evaluated in 31 cases of biopsy-proven OSCC by immunohistochemical staining and its association with prognosticators and the Brynes grading system was determined by appropriate statistical analysis. Results: We observed a significant increase in linear staining pattern (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c371dbab0a97b4ba6bccab9a8d133dbb http://europepmc.org/articles/PMC5980927 Zobrazit plný text záznamu