[Therapeutic approaches using genetically modified cells]

Autor:	Brigitte, Anliker, Matthias, Renner, Matthias, Schweizer
Jazyk:	němčina
Rok vydání:	2015
Předmět:	Neoplasms Recombinant Fusion Proteins T-Lymphocytes Therapies Investigational Cell- and Tissue-Based Therapy Immunologic Deficiency Syndromes Receptors Antigen T-Cell Humans Genetic Therapy Immunotherapy Genetic Engineering
Zdroj:	Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz. 58(11-12)
ISSN:	1437-1588
Popis:	Medicinal products containing genetically modified cells are, in most cases, classified as gene therapy and cell therapy medicinal products. Although no medicinal product containing genetically modified cells has been licensed in Europe yet, a variety of therapeutic strategies using genetically modified cells are in different stages of clinical development for the treatment of acquired and inherited diseases. In this chapter, several examples of promising approaches are presented, with an emphasis on gene therapy for inherited immunodeficiencies and on tumour immunotherapy with genetically modified T-cells expressing a chimeric antigen receptor or a recombinant T-cell receptor.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c368134bd26edf2ca00753ed664e0e42 https://pubmed.ncbi.nlm.nih.gov/26349563 Zobrazit plný text záznamu Full text from SpringerLink