[Expression and significance of HGAL and LMO2 in follicular lymphoma]

Autor:	Fen, Zhang, Donglan, Luo, Xinlan, Luo, Yu, Chen, Jie, Xu, Jie, Chen, Hengguo, Zhuang, Yanhui, Liu
Rok vydání:	2016
Předmět:	Proto-Oncogene Proteins Microfilament Proteins Biomarkers Tumor Intracellular Signaling Peptides and Proteins Proto-Oncogene Proteins c-bcl-6 Humans Neprilysin LIM Domain Proteins Germinal Center Immunohistochemistry Lymphoma Follicular Adaptor Proteins Signal Transducing Neoplasm Proteins
Zdroj:	Zhonghua bing li xue za zhi = Chinese journal of pathology. 45(2)
ISSN:	0529-5807
Popis:	To evaluate the diagnostic value of HGAL and LMO2 expression and compare with CD10 and bcl-6 in follicular lymphoma (FL).63 cases of FL were collected from Guangdong General Hospital. The expression of HGAL, LMO2, CD10 and bcl-6 was assessed by immunohistochemistry.The expression rates of HGAL, LMO2, CD10 and bcl-6 were 98.4% (62/63), 82.5% (52/63), 82.5% (52/63) and 87.3% (55/63), respectively. The expression rate of HGAL was higher than those of LMO2, CD10 and bcl-6, but the differences were not significant (P0.05). There was no significant difference in HGAL, LMO2 and bcl-6 expression among FL1, FL2 and FL3 cases. The CD10 expression rate of FL1-3A cases was significantly higher than that of FL3B cases(P0.01).HGAL and LMO2, especially HGAL, can be used in FL particularly high grade FL as useful germinal center marker.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c354f3e8021335824bc531f9fa7f63a2 https://pubmed.ncbi.nlm.nih.gov/26879427 Zobrazit plný text záznamu