Prostate-specific Membrane Antigen Imaging in Recurrent Medullary Thyroid Cancer: A New Theranostic Tracer in the Offing?

Autor:	Arora, Saurabh, Prabhu, Meghana, Damle, Nishikant Avinash, Bal, Chandrasekhar, Kumar, Praveen, Nalla, Harish, Arun Raj, Sreedharan Thankarajan
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	68Ga-prostate-specific membrane antigen medullary thyroid carcinoma Interesting Image positron emission tomography/computed tomography 68Ga-DOTANOC urologic and male genital diseases
Zdroj:	Indian Journal of Nuclear Medicine : IJNM : The Official Journal of the Society of Nuclear Medicine, India
ISSN:	0974-0244 0972-3919
Popis:	Prostate-specific membrane antigen (PSMA) expression has been shown in neovasculature of various malignancies. Recurrent medullary thyroid cancer (MTC) is difficult to treat. We present the findings on PSMA-positron emission tomography/computed tomography (PET/CT) of a 68-year-old man with MTC, who presented with a recurrent left paratracheal mass and rising calcitonin. The scan revealed significant uptake on PSMA imaging but not on 68Ga-DOTANOC PET/CT. 177Lu-PRRT is one of the therapeutic options in patients with recurrent MTC, but in this case was not possible due to lack of somatostatin receptor expression. Imaging evidence of PSMA expression alerts us to the potential use of 177Lu-DKFZ-PSMA-617 therapy in such patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c2e384b470fdbc9724736694b4e6616b http://europepmc.org/articles/PMC6011559 Zobrazit plný text záznamu Plný text ve formátu PDF