Chiral aminophosphonate eluent for enantiomeric analysis of amino acids

Autor:	Y P, Belov, A Y, Aksinenko, B, Blessington, A H, Newman
Rok vydání:	1996
Předmět:	Spectrophotometry Infrared Indicators and Reagents Stereoisomerism Amino Acids Hydrogen-Ion Concentration Chromatography Ion Exchange
Zdroj:	Chirality. 8(1)
ISSN:	0899-0042
Popis:	An aqueous solution of the (+)-monoethyl ester of N-(1'-hydroxymethyl)propyl-alpha-aminobenzylphosphonic acid has been proposed as a suitable chiral eluent for enantiomeric analysis of amino acids by ligand-exchange chromatography. Asymmetric synthesis of the chiral selector using (-)-(R)-2-aminobutan-1-ol as a starting reactant is described. The dependence of the parameters of separation of valine enantiomers on concentration of the complexing ion, pH, and temperature has been investigated. It is shown that the order in which enantiomers are eluted from a column depends on the concentration of the complexing ion and pH.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c2e176780fea2c3250cc12c1d7918ace https://pubmed.ncbi.nlm.nih.gov/8845275 Zobrazit plný text záznamu Plný text