Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome

Autor:	Robert Tanner, Hagelstrom, James, Ford, Gwendolyn M, Reiser, Marilu, Nelson, Diane L, Pickering, Pamela A, Althof, Warren G, Sanger, Peter F, Coccia
Rok vydání:	2015
Předmět:	Adult Male Lymphoma Non-Hodgkin Humans Child Hamartoma Syndrome Multiple Breast Neoplasms Male Pedigree
Zdroj:	Pediatric bloodcancer. 63(3)
ISSN:	1545-5017
Popis:	Male breast cancer (MBC) is unusual, especially in young adults. Most cases of MBC as a secondary malignancy relate to the previous treatment with ionizing radiation. MBC can be associated with mutations in hereditary cancer predisposition syndrome genes (i.e., BRCA2); however, no such association has been reported in patients with Cowden syndrome (involving the phosphatase and tensin homolog [PTEN] gene). We describe a patient with Cowden syndrome who was initially diagnosed with B-cell lymphoblastic lymphoma at the age of 7 years, then MBC at the age of 31 years, and never received radiation therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c2d924c8d35ddd26ca9fdcc4862f0ac3 https://pubmed.ncbi.nlm.nih.gov/26468640 Zobrazit plný text záznamu Plný text