Comparative investigations of hydroxyamine carane derivative and its R,S-diastereoisomers with strong local anesthetic activity

Autor: T, Librowski, R, Czarnecki, S, Lochyński, B, Frackowiak, M, Pasenkiewicz-Gierula, J, Grochowski, P, Serda
Rok vydání: 2002
Předmět:
Zdroj: Polish journal of pharmacology. 53(5)
ISSN: 1230-6002
Popis: Our previously conducted pharmacological screening led as to the discovery of the strong local anesthetic activity of the compound designated as KP-23. Earlier crystallographic studies revealed that the compound KP-23 crystallized in diastereoisomeric form in lowest symmetry. The aim of these comparative investigations was to evaluate anesthetic activity of KP-23 and its R,S-diastereoisomers, which were synthesized at the Institute of Organic Chemistry, Biochemistry and Biotechnology, Wroclaw University of Technology.
Databáze: OpenAIRE