Evidence for a correlation between antibody-dependent cellular cytotoxicity-mediating anti-HIV-1 antibodies and prognostic predictors of HIV infection

Autor:	R, Ahmad, S T, Sindhu, E, Toma, R, Morisset, J, Vincelette, J, Menezes, A, Ahmad
Rok vydání:	2001
Předmět:	Killer Cells Natural Antibody-Dependent Cell Cytotoxicity HIV-1 Humans RNA Viral HIV Infections Viremia HIV Antibodies Prognosis CD4 Lymphocyte Count Clone Cells
Zdroj:	Journal of clinical immunology. 21(3)
ISSN:	0271-9142
Popis:	Using our gp120/41-expressing, NK cell activity-resistant CEM.NKR cell clones as targets in HIV-1-specific antibody-dependent cellular cytotoxicity (ADCC) assays, we demonstrate here that the serum titers of anti-HIV-1 ADCC antibodies bear a significant (P0.05) positive correlation with the peripheral blood CD4+ T cell counts and a negative one with the number of copies of HIV-1 RNA in the plasma of HIV-infected individuals. These findings underscore the importance of these antibodies as a protective immune parameter in these infections.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c26fa48355bb8c046d94f77b0ccbade6 https://pubmed.ncbi.nlm.nih.gov/11403230 Zobrazit plný text záznamu Full text from SpringerLink