Optimization of magnetization transfer experiments to measure first-order rate constants and spin-lattice relaxation times

Autor:	H, Katki, G H, Weiss, J E, Kiefer, H, Taitelbaum, R G, Spencer
Rok vydání:	1996
Předmět:	Adenosine Triphosphatases Kinetics Magnetics Adenosine Triphosphate Magnetic Resonance Spectroscopy Phosphocreatine Animals Creatine Kinase Mathematical Computing Rats
Zdroj:	NMR in biomedicine. 9(3)
ISSN:	0952-3480
Popis:	A recent analysis of the optimization of magnetization transfer experiments to estimate first-order rate constants is extended to the design of experiments for measuring these constants and T1 when both parameters are initially unknown. When the number of measurement times is fixed, an optimal design will consist of a set of measurement times which ensures that the precision of the estimates of the combination of k and T1 is as small as possible in a worst-case scenario. Simple expressions are given for the parameters that characterize the optimal design.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c23bf94bcfe334fc901bb5d9b25fe669 https://pubmed.ncbi.nlm.nih.gov/8892400 Zobrazit plný text záznamu Plný text