| Autor: |
Li-li, Wang, Yan-chen, Xie, Shi-fang, Hou, Kai, Feng, Jian, Yin, Xian-hao, Xu, Zun-bo, Li, Ying-peng, Wang, Ting, Xiong, Jian-jun, Liu, Ding-guo, Shen |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Zhonghua yi xue za zhi. 89(43) |
| ISSN: |
0376-2491 |
| Popis: |
To investigate the association of two glucocorticoid receptor (GR) polymorphisms (BclI, ER22/23EK) with Myasthenia Gravis (MG).The genotypes of GR in 61 MG patients (MGG) and 57 age and gender-matched healthy controls (HCG) were determined by polymerase chain reaction and nucleotide sequence determination.The frequencies of three genotypes (GG, CG, CC) in BclIwere 3.3%, 34.4%, 62.3% in MGG and 3.5%, 38.6%, 57.9%in HCG respectively. The difference in the distribution of genotypes between MGG and HCG was statistically insignificant (P = 0.887). The frequencies of G and C allele were 20.5% vs 79.5 %in MGG, and 22.8% vs 77.2% in HCG. The difference in the distribution of alleles between MGG and HCG was statistically insignificant (P = 0.968). The genotype frequencies in two groups were both in Hardy-Weinberg equilibrium (P0.05). The genotypes of ER22/23EK in MGG and HCG were all GG and no mutation was detected.BclI and ER22/23EK polymorphisms of GR have no definite relationship with the risk of MG. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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