| Autor: |
N, Mestdagh, N, Pommery, J M, Saucier, B, Hecquet, C, Fournier, C, Slomianny, E, Teissier, J P, Hénichart |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
Anticancer research. 14(3A) |
| ISSN: |
0250-7005 |
| Popis: |
Resistance to antineoplastic drugs has often been associated with P-glycoprotein overexpression, this certainly being not the sole mechanism. In order to characterize resistance to doxorubicin and cisplatin, we have analysed P-glycoprotein expression, topoisomerase II activity, glutathione and related enzymes in murine leukemic cells (doxorubicin or cisplatin-resistant). The doxorubicin-resistant cells contained P-glycoprotein, showed lower activities of glutathione S-transferase well as of glutathione reductase and topoisomerase II. The modifications observed in the most cisplatin-resistant cell line were a higher activity of glutathione S-transferase isoenzyme pi and topoisomerase II. These results suggest that drug uptake, glutathione metabolism as well as topoisomerase II activity are all characteristic of multidrug resistance. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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