Clinical characteristics of post-treatment reactions to ivermectin/albendazole for Wuchereria bancrofti in a region co-endemic for Mansonella perstans
| Autor: | Paul B, Keiser, Yaya I, Coulibaly, Falaye, Keita, Diakaridia, Traore, Abdallah, Diallo, Dapa A, Diallo, Roshanak T, Semnani, Ogobara K, Doumbo, Sekou F, Traore, Amy D, Klion, Thomas B, Nutman |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Ivermectin Adolescent Mansonella Middle Aged Albendazole Mali Drug Administration Schedule Filariasis Filaricides Surveys and Questionnaires Outcome Assessment Health Care Prevalence Adverse Drug Reaction Reporting Systems Animals Humans Drug Therapy Combination Female Wuchereria bancrofti Aged |
| Zdroj: | The American journal of tropical medicine and hygiene. 69(3) |
| ISSN: | 0002-9637 |
| Popis: | Post-treatment reactions to single-dose ivermectin (200 microg/kg) and albendazole (400 mg) were studied in a filarial endemic region of Mali. The prevalence of Wuchereria bancrofti in this region was 48.3% (69 of 143), and coinfection with Mansonella perstans was common (30 of 40, 75%). Microfilarial levels of M. perstans correlated positively with age (P = 0.006) and with W. bancrofti microfilarial levels (P = 0.006). Forty individuals (28 infected and 12 uninfected) were treated, with mild post-treatment reactions occurring in 35.7% (7 of 28) of the W. bancrofti-infected subjects. Reaction severity correlated with pretreatment W. bancrofti microfilarial levels (P = 0.001). There were no significant differences in the prevalence or severity of post-treatment reactions in those who were co-infected with M. perstans. It is concluded that co-infection with M. perstans does not significantly alter the post-treatment reaction profile to single-dose ivermectin/albendazole in W. bancrofti infection in this community, and that acute post-treatment reactions should not limit patient compliance in community-based programs to eliminate lymphatic filariasis. |
| Databáze: | OpenAIRE |
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