A cross-sectional epidemiological study of HBV, HCV, HDV and HEV prevalence in the SubCarpathian and South-Eastern regions of Romania
| Autor: | Mihai, Voiculescu, Laura, Iliescu, Camelia, Ionescu, Laurentiu, Micu, Gener, Ismail, Diana, Zilisteanu, Andreea, Radasan, Georgia, Micu, Ioana, Pertache |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Hepatitis B virus Adolescent Hepacivirus Risk Assessment Young Adult Sex Factors Renal Dialysis Risk Factors Seroepidemiologic Studies Occupational Exposure Hepatitis E virus Prevalence Humans Hepatitis B e Antigens Hepatitis B Antibodies Child Aged Aged 80 and over Hepatitis B Surface Antigens Romania Age Factors Infant Newborn Infant Alanine Transaminase Hepatitis C Antibodies Middle Aged Hepatitis B Hepatitis C Hepatitis D Hepatitis E Cross-Sectional Studies Child Preschool DNA Viral RNA Viral Female Hepatitis Delta Virus Biomarkers |
| Zdroj: | Journal of gastrointestinal and liver diseases : JGLD. 19(1) |
| ISSN: | 1841-8724 |
| Popis: | To evaluate the prevalence of HBV, HCV, HDV and HEV infections in populations with different categories of risk and the seroprevalence of HBV and HCV infections in subjects asking for a medical examination.We conducted a cross-sectional, epidemiological study in 2,851 subjects from the SubCarpathian and South-Eastern Romania (including 17 counties, 34% of the country area and 42% of the population). The subjects were divided into four groups: controls (n=2,540, i.e. consecutive subjects asking for a medical examination), subjects with very low risk (students; n=44), with low risk (doctors and nurses; n=93) and with high risk for viral hepatitis (hemodialysis patients; n=174). All subjects were screened for HBsAg, antiHCV and ALT level. In populations at risk, antiHBs, HBeAg, antiHBe, antiHBc (IgG), HBV-DNA, HCV-RNA, antiHDV(IgG) and antiHEV(IgG) were also assessed.In controls, HBV seroprevalence was 5.59% and HCV seroprevalence 4.56%. The risk factors for HBV infection were: age, male gender and South-East region of Romania. The risk factors for HCV infection were: age, female gender, elevated ALT level and the South-East region of Romania. In the very low risk population HBV, HCV, HDV and HEV seroprevalence was: 2.27%, 0%, 0% and 12.5%, respectively. In low risk population the seroprevalence was 2.15%, 1.07%, 0% and 13.98%. In hemodialysis patients, HBV and HCV seroprevalence were 7.91%, respectively 39.26%. HCV-RNA was detectable in 20.69% cases.In the South and South-Eastern Romania the seroprevalence of viral hepatitis infections is intermediate, similar to other Romanian regions or the Balkans. |
| Databáze: | OpenAIRE |
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