| Autor: |
B, Repetto, G, Bandara, G A, Wiggan, A M, Gilfillan, J P, Kochan |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
International archives of allergy and immunology. 107(1-3) |
| ISSN: |
1018-2438 |
| Popis: |
Chimeric receptors containing the Fc epsilon RI alpha and gamma subunit domains were constructed, stably transfected into RBL-2H3 cells, and characterized for the biochemical events which are elicited upon receptor aggregation. Chimeric receptors containing the extracellular (EC) domain of the human Fc epsilon RI alpha subunit, or the EC domain of the p55 subunit of the interleukin-2 receptor were fused to the human Fc epsilon RI gamma subunit transmembrane and cytoplasmic (CT) domains or only the CT domain. The chimeras generated included alpha/gamma/gamma, I/gamma/gamma, alpha/I/gamma or I/I/gamma. The results indicate that both the Fc epsilon RI alpha EC domain and the Fc epsilon RI alpha CT domain are essential for signalling. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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