[Effect of carminomycin on the enzyme systems of the metabolism of active forms of oxygen and on free-radical lipid oxidation in August rats with Walker carcinosarcoma 256]

Autor:	Sh S, Tazhibaev, E G, Lenskaia, K Kh, Khasenova, N M, Karsybekova, N R, Alekseeva
Rok vydání:	1989
Předmět:	Male Free Radicals Superoxide Dismutase Viscosity Carubicin Daunorubicin Drug Evaluation Preclinical Rats Inbred Strains Catalase Rats Membrane Lipids Oxygen Consumption Microsomes Liver Animals Lipid Peroxidation Carcinoma 256 Walker Neoplasm Transplantation
Zdroj:	Eksperimental'naia onkologiia. 11(4)
ISSN:	0204-3564
Popis:	The influence of carminomycin (CM) on enzymic systems of metabolism of oxygen active forms, free radical lipid peroxidation and microviscosity of membrane lipids as well as toxic and antitumour action of CM were studied in normal and tumour-bearing rats. Detected responses of the system of superoxide anion- and H2O2 metabolism reflected the role of active oxygen forms in CM toxicity. The investigation results of the lipid peroxidation fluorescent products level and microsomal lipid phase microviscosity did not suppose stimulation of lipid peroxidation as key mechanism for CM toxic effects. Problems on the prevention and treatment of anthracyclines side effects are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c1c0b49ff29576dde35785053287b37e https://pubmed.ncbi.nlm.nih.gov/2759014 Zobrazit plný text záznamu