| Autor: |
D P, Kofteridis, G, Notas, S, Maraki, T, Anastasopoulos, G, Papazoglou, A T, Zisiou, E, Mantadakis, G, Samonis |
| Rok vydání: |
2008 |
| Předmět: |
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| Zdroj: |
Chemotherapy. 54(6) |
| ISSN: |
1421-9794 |
| Popis: |
Haemophilus influenzae is an important human pathogen.The purpose of the present retrospective study is to describe the antibiotic susceptibility to several common antibiotics of 930 consecutive clinical isolates of H. influenzae over the period of 1996-2005 in a tertiary general hospital on the island of Crete, Greece.Overall, 9.5% of the isolates were beta-lactamase producing. Resistance to ampicillin and amoxicillin-clavulanate was observed in 11 and 0.6% of the strains, respectively, remaining stable throughout the study period. Resistance to tetracycline increased from 1.6% in 1996 to 38% in 2005, while resistance to ciprofloxacin and ofloxacin was1%. A significant decrease in resistance to trimethoprim-sulfamethoxazole was observed during the study period. No significant changes in resistance to other antimicrobials were seen.Amoxicillin-clavulanate and older quinolones remain potent agents against H. influenzae. Constant surveillance ofantibiotic susceptibility of H. influenzae clinical isolates is important in order to guide appropriate empirical antibiotic therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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