Responses to human rhinovirus in CD45 T cell subsets isolated from tonsil

Autor:	S, Wilamasundera, D R, Katz, B M, Chain
Rok vydání:	1998
Předmět:	Antigen Presentation Rhinovirus T-Lymphocyte Subsets T-Lymphocytes Palatine Tonsil Humans Leukocyte Common Antigens Antigens Viral Cells Cultured
Zdroj:	European journal of immunology. 28(12)
ISSN:	0014-2980
Popis:	Isotypes of CD45 have been used extensively as markers of memory and naive populations of T cells in peripheral blood. In this study, T cells were isolated from human tonsil and their proliferative response against human rhinovirus was measured. Unexpectedly, equivalent responses were found among the CD4+CD45RA+ and CD4+CD45RO+ populations of T cells. This response requires MHC class II-positive antigen-presenting cells. The time course of the T cell response in vitro was that of a classical recall response, and no proliferative response to the virus could be detected in human cord blood. These results suggest that tonsils contain a significant population of CD45RA+ memory cells. The presence of this population may reflect ongoing stimulation with this common infectious agent, and the anatomical location of the T cells within the major lymphoid organ draining the naso-pharyngeal epithelial surface.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c1a737b747a15719164080742f82d869 https://pubmed.ncbi.nlm.nih.gov/9862374 Zobrazit plný text záznamu Plný text